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| Drug Update... |
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Respiratory Drugs A fixed combination product containing salmeterol xinafoate (a selective long-acting B2 adrenoceptor agonist and bronchodilator) and fluticasone propionate (an inhaled glucocorticoid with anti-inflammatory activity) was introduced last year for the treatment of asthma in adults and children above the age of four. This product is expected to significantly improve patient compliance in asthma patients. This combination is at least as effective as separate administration of the two drugs and is well tolerated and convenient. Albuterol (salbutamol), the most widely administered bronchodilator, exists as a racemic mixture of equal parts of R and S enantiomers, two non-superimposable, mirror-image molecules. However, studies have implicated the S-isomer in the development of tolerance to B-agonists, increase in the bronchial hyperresponsiveness and undersirable cardiovascular side effects of albuterol. Levalbuterol hydrochloride is a newly introduced signle-isomer version of albuterol; it retains the bronchodilator efficacy of racemic albuterol but is devoid of the deleterious effects of the S-isomer. It is available in the nebulised form and is indicated for the treatment and prevention of bronchospasm in adults and adolescents aged 12 or more with reversible obstructive airway disease. |
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